Risk free rate

Pembrolizumab achieves pre-specified event-free survival in high-risk TNBCs

Patients with high-risk, early-stage triple-negative breast cancer (TNBC) in the phase 3 KEYNOTE-522 study (NCT03036488) with pembrolizumab (Keytruda) plus chemotherapy after surgery demonstrated event-free survival ( SSE) statistically significant, according to a press release from Merck.1 Compared with preoperative chemotherapy, an interim Data Monitoring Committee analysis revealed that neoadjuvant pembrolizumab …

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Pembrolizumab clinical trial shows improvement in event-free survival in high-risk, early-stage triple-negative breast cancer

The KEYNOTE-522 trial met its two primary endpoints of complete pathologic response and event-free survival, showing statistically significant and clinically significant improvement in SES compared to neoadjuvant chemotherapy alone. A pivotal study of pembrolizumab (Keytruda, Merck) in combination with chemotherapy showed statistically significant improvements in event-free survival (ESS) in patients …

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Medium to long term bonds, the sweet spot

Improvements in economic activity driven by external demand reduce the likelihood of further easing by iFAST RESEARCH / Photo by MUHD AMIN NAHARUL AT Monetary Policy Committee (MPC) meeting last Thursday, Bank Negara Malaysia (BNM) kept the overnight key rate (OPR) at 1.75%, as predicted by iFAST Research and the …

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Protect portfolios against interest rate risk

In general, long-dated, low-coupon bonds, such as treasury bills, are more sensitive to changes in interest rates. Meanwhile, bonds with higher coupons and shorter maturities, such as High yield bonds, have shorter terms or are less sensitive to interest rate fluctuations. Figure 1 compares the performance between a low duration …

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More than $ 8 million in fines – SAP case highlights sanctions risks and compliance expectations for cloud providers and software companies – International law

United States: More than $ 8 million in fines – SAP case highlights sanctions risks and compliance expectations for cloud providers and software companies May 07, 2021 Kelley Drye and Warren LLP To print this article, simply register or connect to Mondaq.com. Last week, three American agencies – the Foreign …

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PPF withdrawal rules before maturity

The Public Provident Fund or PPF is an investment and tax saving tool. In the long run, the PPF interest rate (currently 7.1 percent) helps an investor beat inflation as well. Thus, among the risk-free investment options, PPF is one of the most popular options for investors who have a …

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Update on the number of cases and vaccine distribution

Submitted by San Juan County Note: Current positive case counts are available online on the County Case Data Dashboard at sanjuanco.com/1682/COVID-19-SJC-Data-Dashboard. As noted on this page, these figures are only updated after confirmation of the case, usually daily. It is possible that other sources of information in the community will …

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Bonds are not overvalued. They are a warning sign

Many comments suggest that bonds have been overvalued due to historically low rates. “Actions are expensive, but bonds are hugely overvalued over the long term ”- Jeremy siegel However, is this the case? There is no argument that stocks are highly overvalued. We’ve spent much of the past week discussing …

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7 best ECG monitors for personal use in 2021

We include products that we think will be useful for our readers. If you buy through links on this page, we may earn a small commission. Here is our process. ECG or EKG stands for electrocardiogram. An ECG monitor measures and records your heart rate and rhythm, and displays this …

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6 ETFs to Boost Your Portfolio Return

I probably don’t need to tell you that liquidity in today’s financial markets is barely paying anything. Whether it’s bank money markets, savings accounts, or money market mutual funds, returns are in most cases 0% or very close. With the Fed aiming to keep rates as low as possible indefinitely, …

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Strategically speaking: Cardano | Interviews

However, the current economic policy toolkit fails to take into account the human element, making crises potentially more frequent and destructive. The effects of the 2008 financial crisis were still being felt as Theo Kocken, the founder of the British and Dutch consultancy Cardano, began work on the production of …

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Lessons from the Johnson & Johnson vaccine saga

Friday night, the Food and Drug Administration and the Centers for Disease Control and Prevention ended their ten day break on the use of Johnson & Johnson COVID-19 vaccine, which is, overall, great news. The J. & J. vaccine (also called Janssen, for the subsidiary of the company responsible for …

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Persistent Keytruda Effects after 3.5 Years in High-Risk Melanoma

Over a median of 3.5 years of follow-up, adjuvant treatment with Keytruda (pembrolizumab) significantly improved distant metastasis-free survival in patients with resected high-risk stage 3 cutaneous melanoma compared to placebo, according to the data. published in Lancet oncology. “The treatment differences in distant metastasis-free survival rates over time were consistent …

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Does Masturbation Increase Blood Pressure?

Your blood pressure is a measure of the force of your blood against the walls of your arteries. If you have high blood pressure, you are at increased risk of developing serious illnesses such as heart attack, stroke, and heart failure. It is normal for your blood pressure and heart …

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COVID-19 vaccine: when supply exceeds demand

By Ernie Mundell HealthDay Reporter WEDNESDAY April 21, 2021 Since the first COVID-19 vaccine was approved in December, millions of Americans have eagerly sought to find and receive one. But a new report finds that that could change in the coming weeks, as the pool of impatient recipients shrinks and …

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Central banks must act now on climate change

The writer is Managing Director of Fidelity International “There have been three great inventions since the dawn of time”, the American humorist Will Rogers would have said: “The fire, the wheel and the central bank”. Rogers made his comment about a century ago, and central banks are now more influential …

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Lane County will return to ‘high risk’ on Friday

To provide our community with important public safety information, The Register-Guard is making this coronavirus update free to read. To support local journalism like this, please consider becoming a subscriber. For nearly four weeks, businesses and restaurants in Lane County could operate with more people inside for longer hours due …

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India’s G-SAP vs. Japan’s yield curve control policy

The Reserve Bank of India (RBI), India’s central bank, recently announced its Government Securities Acquisition Program (G-SAP). As part of this program, RBI has made an explicit commitment to purchase ₹1 trillion outstanding government securities (G-secs) on the market during the April-June 2021 quarter. The first round of purchases is …

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Your journey to financial freedom

Reading time: 4 minutes The ongoing coronavirus pandemic has crumbled the global economy. For those who live paycheck to paycheck, it has been a never-ending nightmare. However, those who achieved financial freedom before the pandemic are reaping the rewards. If there is anything to learn from this, it is that …

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4 good uses for your stimulation test

Don’t let your stimulus check go to waste. Since mid-March, the IRS has made 127 million stimulus payments as part of President Biden’s efforts to restore the economy and help struggling families during the COVID-19 pandemic. This is the third stimulus payment, valued at $ 1,400 per eligible American. This …

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What does the tip of Libor imply for PFI contracts?

The Infrastructure and Initiatives Authority (IPA) has revealed a PFI Steering Word (Word) on the abandonment of the London Interbank Provided Fee (LIBOR) utilized to PFI tasks. The primary goal of the notice is to boost consciousness amongst contracting authorities of the approaching change in UK monetary markets ensuing from …

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